Protein Polymer Technologies Reports Year End 2001 Finanacial Result

    SAN DIEGO, March 5 -- Protein Polymer Technologies, Inc. (OTC Bulletin Board: PPTI), reports today its financial results for the fourth quarter and the year ended December 31, 2001. For the quarter, the Company had a net loss applicable to common shareholders of $863,000 ($0.04 a share), versus a net loss of $444,000 ($0.02 a share) for the comparable period a year ago. For the year, PPTI had a net loss applicable to common shareholders of $3,424,000 ($0.16 a share), versus a net loss of $2,776,000 ($0.16 a share) for the comparable period a year ago. The net loss, and the net loss per share amounts include accumulated and distributed dividends related to the CompanyÕs preferred stock.

    Contract and licensing revenue, and product and interest income totaled $241,000 for the fourth quarter and $830,000 for the twelve month period ended December 31, 2001, compared to $525,000 and $1,189,000 respectively for the same periods last year. The contract and licensing revenue primarily represents the amortized portion of an up-front license payment of $1 million that is associated with the formation of a partnership with Femcare Ltd., of Nottingham England to commercialize the CompanyÕs product for the treatment of female stress urinary incontinence in Europe and Australia, and from research and development payments from the CompanyÕs affiliate, SpinalWave, Inc., formed with Windamere Venture Partners in April 2001 to develop and commercialize a Spinal disc repair product for the treatment of lower back pain. The $1 million Femcare license fee is being recognized as income over a three-year period.

    Operating expenses for the quarter were $1,034,000, as compared to $899,000 for the same period in 2000. Operating expenses for the year were $3,977,000 as compared to $3,688,000 for the same period in 2000. In general, operating expenses for the past two years have remained low due primarily to reductions in personnel and expenditures implemented during 1999. To the extent that resources become available, expenses are expected to rise in subsequent quarters due to the increased expenditures for expanded human clinical testing and patient follow-up of the CompanyÕs injectable urethral bulking agent for the treatment of female stress urinary incontinence, and of the CompanyÕs injectable hydrogel for the treatment of dermal contour defects (scars, wrinkles, and lines), however, their can be no assurance that additional resources will become available.

    PPTIÕs cash balance as of December 31, 2001 was $234,000, as compared to $866,000 as of December 31, 2000. In January 2002, the Company received $990,000 in additional capital from the exercise of outstanding common stock warrants. In combination with anticipated additional contract and license payments, and revenue projected for the delivery of clinical testing materials, the CompanyÕs cash is expected to meet the CompanyÕs anticipated capital requirements through June 2002. If additional capital is not obtained in the near future, the Company will be required to reduce the use of cash through layoffs and other cost reduction steps.

    Protein Polymer Technologies, Inc., is a biotechnology company focused on developing products to improve medical and surgical outcomes. From its inception in 1988, PPTI has been a pioneer in protein design and synthesis, developing an extensive portfolio of proprietary biomaterials. These genetically engineered biomaterials are high molecular weight proteins, processed into products with physical and biological characteristics tailored to specific clinical performance requirements. Targeted products include urethral bulking agents for the treatment of stress urinary incontinence, dermal augmentation products for cosmetic and reconstructive surgery, surgical adhesives and sealants for repair of Spinal discs, scaffolds for wound healing and tissue engineering, and depots for local drug delivery.

This press release may contain forward-looking statements that are based on management's expectations. Actual results could differ materially from those expressed here; further, the Company is not obligated to comment specifically on those differences. Risks associated with the Company's activities include raising adequate capital to continue operations, scientific and product development uncertainties, competitive products and approaches, continuing collaborative partnership interest and funding, regulatory testing and approvals, and manufacturing scale-up. The reader is encouraged to refer to the Company's Annual Report Form 10-KSB, and recent filings with the Securities and Exchange Commission, copies of which are available from the Company, to further ascertain the risks associated with the above statements.
                       Protein Polymer Technologies, Inc.
                          Condensed Financial Statements
                                   (unaudited)


                         Three months ended           Twelve months ended
                            December 31,                  December 31,
                          2001          2000            2001          2000

    SUMMARY OF OPERATIONS

    Contract revenue   $233,334       $514,156       $783,334     $1,107,396
    Interest income       1,921         10,894         40,778         79,087
    Product and other
     income               5,912             --          5,950          3,012
      Total revenues    241,167        525,050        830,062      1,189,495

    Total expenses    1,034,019        898,812      3,976,890      3,387,572

    Net loss          $(792,852)     $(373,762)   $(3,146,828)   $(2,498,077)

    Undeclared and/or
     paid accumulated
     dividends on
     Preferred Stock     69,980         69,980        277,639        277,639

    Net loss applicable
     to common
     shareholders     $(862,832)     $(443,742)   $(3,424,467)   $(2,775,716)

    Loss per share       $(0.04)        $(0.02)        $(0.16)        $(0.16)

    Weighted average
     shares used in
     computing loss
     per share       21,740,650     18,910,313     20,964,233     17,771,744


                                             As of                As of
                                         Dec. 31, 2001        Dec. 31, 2000
    BALANCE SHEET INFORMATION                                     (audited)
    Cash and cash equivalents                $234,000              $866,000
    Working capital                          (585,000)              143,000
    Total assets                              527,000             1,383,000
    Total capital invested                 42,492,000            40,014,000
    Accumulated deficit                  $(42,890,000)         $(39,744,000)