PROTEIN POLYMER TECHNOLOGIES AND GENENCOR AMEND WORLDWIDE LICENSING AGREEMENT TO INCLUDE NON-MEDICAL PERSONAL CARE PRODUCTS

SAN DIEGO, October 15, 2002 -- Protein Polymer Technologies, Inc. (OTC Bulletin Board: PPTI.OB), today announced the amendment of its worldwide exclusive license agreement with Genencor International, Inc. enabling Genencor to potentially develop personal care products in addition to the previously granted rights for industrial products. As a result of the agreement amendment, Genencor can use PPTI’s proprietary protein polymer design and production technology, in combination with Genencor’s extensive gene expression, protein design, and large-scale manufacturing technology, to design and develop new products with improved performance properties for hair care, skin care and other personal care applications. PPTI continues to retain all rights to its technology for use in the development and commercialization of medical products.

Genencor International is a world leader in the development and manufacture of industrial enzymes and other biotechnology products. Protein Polymer Technologies, whose internal product focus is primarily medical, holds the fundamental patents on the design and development of de novo proteins that in form are highly repetitive polymers with predictable physical and biological properties. The option for personal care product applications granted to Genencor requires initiation of specific product development programs in order to retain their rights.  Benchmark payments associated with various product development objectives and royalties on the sale of products developed under the agreement are maintained, except that there is no limit to benchmark payments resulting from personal care products.

"We believe the opportunities in the personal care products market are a better strategic fit with Genencor's capabilities, analagous to the industrial market  areas we previously licensed to Genencor " said J. Thomas Parmeter, PPTI’S President and Chief Executive Officer. “As a result, we expect  PPTI and its stockholders to benefit from this transaction.”

Protein Polymer Technologies, Inc., is a San Diego-based company focused on developing products to improve medical and surgical outcomes. From its inception in 1988, PPTI has been a pioneer in protein design and synthesis, developing an extensive portfolio of proprietary biomaterials. These genetically engineered biomaterials are high molecular weight proteins, processed into products with physical and biological characteristics tailored to specific clinical performance requirements. Targeted products include urethral bulking agents for the treatment of stress urinary incontinence, dermal augmentation products for cosmetic and reconstructive surgery, surgical adhesives and sealants, scaffolds for wound healing and tissue engineering, and depots for local drug delivery. To date, PPTI has been issued twenty-four U.S. Patents on its core technology with corresponding issued and pending patents in key international markets.

This press release may contain forward-looking statements that are based on management's expectations. Actual results could differ materially from those expressed here; further, the Company is not obligated to comment specifically on those differences. Risks associated with the Company's activities include raising adequate capital to continue operations, scientific and product development uncertainties, competitive products and approaches, continuing collaborative partnership interest and funding, regulatory testing and approvals, and manufacturing scale-up. The reader is encouraged to refer to the Company's Annual Report Form 10-KSB, and recent filings with the Securities and Exchange Commission, copies of which are available from the Company, to further ascertain the risks associated with the above statements.

CONTACTS:

J. Thomas Parmeter
President

Janis Y. Neves
Director of Finance & Administration

(858) 558-6064         info@ppti.com