Protein Polymer Reports 1999 Year End Financial Results And $3.5 Million Raised Subsequent to Year End

   SAN DIEGO, March 7 -- Protein Polymer Technologies, Inc. (Nasdaq: PPTI) reports today its 1999 financial results for the fourth quarter and the year, both ended December 31, 1999. In addition, the Company announced it recently had raised $2.1 million through the conversion of common stock warrants held by a small group of accredited and institutional investors. In combination with approximately $1,400,000 in cash and receivables generated from licensing and R&D agreements, PPTI has raised a total of approximately $3.5 million since the beginning of 2000. The Company intends to use the proceeds to continue and expand human clinical testing of the Company's lead product, an injectable treatment for female stress urinary incontinence.
   1999 Financial Results. For the fourth quarter of 1999, the Company had a net loss applicable to common shareholders of $1,295,000, or $.10 per share, versus a net loss of $1,520,000, or $0.14 per share, for the comparable period in 1998. For the year ended December 31, 1999, the Company had a net loss applicable to common shareholders of $4,535,000, or $0.36 per share, versus a net loss of $9,183,000, or $0.88 per share, for the comparable period in 1998. The difference in year end results is due primarily to a non-cash, ``imputed dividends'' expense in 1998 that resulted from the sale and issuance of the Company's Series E Convertible Preferred Stock. Excluding the effect of the imputed dividends, the net loss applicable to common shareholders for 1998 would have been $5,638,000 ($.54 per share).
   Contract revenues, interest, and product income totaled $13,445 for the fourth quarter of 1999, compared to $74,000 for the same period in 1998. For the year, these revenues totaled $96,000, compared to $256,000 for the same period in 1998. The decrease in contract revenue reflects the Company's increased focus on moving the incontinence product into clinical testing, prior to seeking a strategic partner to help defray the development and clinical testing costs. Operating expenses for the fourth quarter were $1,239,000, as compared to $1,526,000 for the same period in 1998. Operating expenses for the year totaled $4,353,000, compared to $5,894,000 for the same period in 1998. For both the fourth quarter and the year, the decreased expenditures were due primarily to a corporate downsizing in mid year, and completion of preclinical testing and reduced regulatory expense in preparation for clinical trials of the Company's soft tissue augmentation products that began in December 1999.
   As of December 31, 1999, the Company had $156,000 in cash and cash equivalents which, in combination with the cash and receivables raised in January and February 2000, the Company believes is sufficient to fund its operations through December 2000. In addition, PPTI is pursuing a number of alternatives to meet the continuing capital requirements of its operations.
   "Our financial results for both the fourth quarter and fiscal year reflect the necessary costs associated with bringing our soft tissue augmentation products into human clinical trials," said Dr. J. Thomas Parmeter, PPTI's President and Chief Executive Officer. "We expect to continue to spend at this level and higher, to the extent capital is available, as we continue clinical trials of our incontinence product this year."
   "Our product pipeline is stronger and better defined than ever before," Dr. Parmeter added. "Our urethral bulking agents are in clinical trials, our dermal and reconstructive product is being prepared for an IDE submission to the FDA for approval, and we've directed the focus of our surgical adhesive technology toward the treatment of lower back pain through Spinal disc repair. We are currently in various stages of discussion with potential strategic partners for both our soft tissue augmentation products and our surgical adhesive product opportunities."
   Subsequent Financing Events. The Company received in January and February 2000 approximately $1,400,000 in cash and receivables primarily from the previously announced licensing and R&D agreements with Femcare, Ltd. for the European and Australian marketing rights to the stress urinary incontinence bulking product, and from Sanyo Chemical Industries, Ltd. for the commercial rights to PPTI's in vitro cell culture business and existing inventory. Also in February 2000, the Company received approximately $2.1 million from the exercise of common stock warrants originally granted as part of the sale of Series G Convertible Preferred Stock and warrants. The Preferred Stock, warrants and underlying common stock have not been registered under the Securities Act of 1933, as amended, and may not be offered or sold in the United States absent registration or an applicable exemption from registration requirements.
   Protein Polymer Technologies, Inc., a San Diego-based biotechnology company, has developed a protein-based technology platform that allows creation of new biomaterials that can target multiple applications in biomedical markets. The different classes of biocompatible polymers developed by PPTI have been genetically engineered to enable cell growth, promote the regeneration of tissue, bond to synthetic surfaces, and resorb into tissue at controlled rates. Targeted applications include tissue adhesives and sealants, tissue augmentation, wound healing, and drug delivery vehicles.

This press release may contain forward-looking statements that are based on management's expectations. Actual results could differ materially from those expressed here; further, the Company is not obligated to comment specifically on those differences. Risks associated with the Company's activities include raising adequate capital to continue operations, scientific and product development uncertainties, competitive products and approaches, continuing collaborative partnership interest and funding, regulatory testing and approvals, and manufacturing scale-up. The reader is encouraged to refer to the Company's Annual Report Form 10-KSB, and recent filings with the Securities and Exchange Commission, copies of which are available from the Company, to further ascertain the risks associated with the above statements.
                        Protein Polymer Technologies, Inc.
                          Condensed Financial Statements
                                   (unaudited)

                              Three months ended        Twelve months ended
                                  December 31,              December 31,
                              1999         1998         1999          1998
    SUMMARY OF OPERATIONS

    Contract revenue           $ --          $ --       $2,320      $50,000
    Interest income           9,768        44,641       39,343      134,978
    Product and other
     income                   3,677        29,827       54,304       70,846
       Total revenues        13,445        74,468       95,967      255,824

    Total expenses        1,238,779     1,525,541    4,353,498    5,894,027

    Net loss            $(1,225,334)  $(1,451,073) $(4,257,531) $(5,638,203)

    Undeclared and/or
     paid accumulated
     dividends on
     Preferred Stock         69,980        69,410      277,639    3,544,323

    Net loss applicable
     to common
     shareholders       $(1,295,314)  $(1,520,483) $(4,535,170) $(9,182,526)

    Loss per share           $(0.10)       $(0.14)      $(0.36)      $(0.88)

    Weighted average
     shares used in
     computing loss
     per share           13,443,510    10,690,097   12,570,987   10,484,277


                                       As of               As of
                                   Dec. 31, 1999       Dec. 31, 1998
    BALANCE SHEET INFORMATION                            (audited)
    Cash and cash equivalents          $156,000          $1,383,000
    Working capital                    (458,000)            600,000
    Total assets                        741,000           2,225,000
    Total capital invested           37,299,000          34,258,000
    Accumulated deficit            $(37,245,000)       $(32,988,000)