Protein Polymer Technologies Reports Second Quarter 2000 Financial Results

    SAN DIEGO, August 7 -- Protein Polymer Technologies, Inc. (OTC Bulletin Board: PPTI), reports today its financial results for the second quarter and the six months ended June 30, 2000. For the quarter, the Company had a net loss applicable to common shareholders of $988,000 ($0.05 a share), versus a net loss of $1,241,000 ($0.10 a share) for the comparable period a year ago. Year-to-date, PPTI had a net loss applicable to common shareholders of $1,535,000 ($0.09 a share), versus a net loss of $2,415,000 ($0.21 a share) for the comparable period a year ago. The net loss, and the net loss per share amounts include accumulated and distributed dividends related to the Company's preferred stock.
    Contract and licensing revenue, and product and interest income totaled $135,000 for the second quarter and $539,000 for the six month period ended June 30, 2000, compared to $20,000 and $56,000 respectively for the same periods last year. The increase in contract and licensing revenue primarily represents the amortized portion of an up front license payment of $1 million that is associated with the formation of a partnership with Femcare Ltd., of Nottingham England to commercialize the Company's product for the treatment of female stress urinary incontinence in Europe and Australia, and from the sale of the Company's in vitro cell culture business to Sanyo Chemical Industries, Ltd. of Kyoto, Japan. The $1 million Femcare license fee is being recognized as income over a three year period.
    Operating expenses for the quarter were $1,054,000, as compared to $1,192,000 for the same period in 1999. Operating expenses for the year-to-date were $1,936,000 as compared to $2,333,000 for the same period in 1999. The lower operating expenses are due primarily to reductions in personnel and expenditures implemented during the summer of last year, and to a lesser degree to reduced research and development expenses following the completion of preclinical testing and approval by the U.S. Food and Drug Administration (FDA) to begin human clinical trials of the Company's injectable urethral bulking agent for the treatment of female stress urinary incontinence. However, to the extent that resources are available, expenses are expected to rise in subsequent quarters due to the increased expenditures for clinical testing and patient follow-up of the incontinence product, and potentially by the initiation of human clinical trials of the Company's dermal filler product for use in cosmetic and reconstructive surgery if the Company's application to begin such tests is approved by the FDA later this year.
    PPTI's cash balance as of June 30, 2000 was $1,759,000. In combination with anticipated additional contract and license payments, and revenue projected for the delivery of clinical testing materials, this amount is expected to meet the Company's anticipated capital requirements until January 2001.
    "We are generally pleased with the Company's progress toward commercializing its tissue augmentation technology. However, our ability to complete U.S. clinical testing of the incontinence product, and to advance the dermal filler product into human clinical trials is dependent on identifying additional sources of working capital," said J. Thomas Parmeter, PPTI's President and Chief Executive Officer. "Over the remainder of the year, the Company will seek to raise additional funds for continuing operations through private or public offerings, and through additional collaborative agreements. In addition to our alliance with Femcare, Ltd., we are in discussions with other potential strategic partners for both of the soft tissue augmentation products. For our redefined surgical adhesives and sealants program, we are seeking to identify a partner for the development of a new injectable Spinal disc repair product for the treatment of lower back pain."

    Protein Polymer Technologies, Inc., is a biotechnology company focused on developing products to improve medical and surgical outcomes. From its inception in 1988, PPTI has been a pioneer in protein design and synthesis, developing an extensive portfolio of proprietary biomaterials. These genetically engineered biomaterials are high molecular weight proteins, processed into products with physical and biological characteristics tailored to specific clinical performance requirements. Targeted products include urethral bulking agents for the treatment of stress urinary incontinence, dermal augmentation products for cosmetic and reconstructive surgery, surgical adhesives and sealants, adhesive fillers for repair of Spinal discs, scaffolds for wound healing and tissue engineering, and depots for local drug delivery.

   This press release may contain forward-looking statements that are based on management's expectations. Actual results could differ materially from those expressed here; further, the Company is not obligated to comment specifically on those differences. Risks associated with the Company's activities include raising adequate capital to continue operations, scientific and product development uncertainties, competitive products and approaches, continuing collaborative partnership interest and funding, regulatory testing and approvals, and manufacturing scale-up. The reader is encouraged to refer to the Company's Annual Report Form 10-KSB, and recent filings with the Securities and Exchange Commission, copies of which are available from the Company, to further ascertain the risks associated with the above statements.

                      Protein Polymer Technologies, Inc.
                        Condensed Financial Statements
                                 (unaudited)


                           Three months ended              Six months ended
                                June 30,                       June 30,
                          2000           1999           2000          1999
    SUMMARY OF OPERATIONS
    Contract revenue   $103,333            $--       $489,907           $--
    Interest income      31,842          6,556         45,651        19,559
    Product and other
     income                 145         13,868          3,012        36,516
      Total revenues    135,320         20,424        538,570        56,075

    Total expenses    1,054,462      1,191,746      1,936,182     2,333,496

    Net loss          $(919,142)   $(1,171,322)   $(1,397,612)  $(2,277,421)

    Undeclared and/or
     paid dividends on
     Preferred Stock     69,220         69,220        137,678       137,678

    Net loss
     applicable to
     common
     shareholders     $(988,362)   $(1,240,542)   $(1,535,290)  $(2,415,099)

    Net loss per common
     share -- basic and
     diluted             $(0.05)        $(0.10)        $(0.09)       $(0.21)

    Shares used in
     computing net
     loss per share
     -- basic and
     diluted         18,377,713     12,505,778     16,849,228    11,727,586


                                                  As of            As of
                                             June 30, 2000    Dec. 31, 1999
    BALANCE SHEET INFORMATION
    Cash and cash equivalents                  $1,759,000          $156,000
    Working capital                               984,000          (458,000)
    Total assets                                2,291,000           741,000
    Total capital invested                     39,609,000        37,299,000
    Accumulated deficit                      $(38,643,000)     $(37,245,000)