Protein Polymer Technologies and Genencor Sign Worldwide Licensing Agreement For the Development of Protein Polymers for Industrial Applications

    SAN DIEGO, December 21 -- Protein Polymer Technologies, Inc. (OTC Bulletin Board: PPTI), today announced the signing of a broad-based, worldwide exclusive license agreement with Genencor International, Inc. enabling Genencor to potentially develop a wide variety of new industrial products. As a result of the agreement, Genencor can use PPTI's proprietary protein polymer design and production technology, in combination with Genencor's extensive gene expression, protein design, and large-scale manufacturing technology, to design and develop new products with improved performance properties for industrial applications. PPTI retains all rights to its technology for use in the development and commercialization of medical products.
    Genencor International is a world leader in the development and manufacture of industrial enzymes and other biotechnology products. Protein Polymer Technologies, whose internal product focus is primarily medical, holds the fundamental patents on the design and development of de novo proteins that in form are highly repetitive polymers with predictable physical and biological properties. In return for the license, Genencor will pay PPTI an upfront license fee, benchmark payments associated with various product development objectives, and royalties on the sale of products developed under the agreement. In addition, PPTI has agreed to provide Genencor with certain contractual R&D services when requested, and Genencor, upon meeting defined objectives, will receive warrants to acquire PPTI common stock.

    Protein Polymer Technologies, Inc., is a San Diego-based company focused on developing products to improve medical and surgical outcomes. From its inception in 1988, PPTI has been a pioneer in protein design and synthesis, developing an extensive portfolio of proprietary biomaterials. These genetically engineered biomaterials are high molecular weight proteins, processed into products with physical and biological characteristics tailored to specific clinical performance requirements. Targeted products include urethral bulking agents for the treatment of stress urinary incontinence, dermal augmentation products for cosmetic and reconstructive surgery, surgical adhesives and sealants, scaffolds for wound healing and tissue engineering, and depots for local drug delivery. To date, PPTI has been issued nineteen U.S. Patents on its core technology with corresponding applications in key international markets.
    Using an integrated set of technology platforms, Genencor International is a diversified biotechnology company focused on developing and commercializing innovative products for the agriculture, industrial chemical, and health care markets. Genencor was established in 1982 as a joint venture between Genentech Inc. and Corning Incorporated. Since its founding, Genencor has grown to become a leading biotechnology company, with over $300 million in 1999 revenues, more than 250 biotechnology products in commerce, and more than 3000 owned and licensed patents and applications. Genencor, with more than 1500 employees worldwide, has principle offices in Palo Alto, California; Rochester, New York; and Leiden, the Netherlands.

This press release may contain forward-looking statements that are based on management's expectations. Actual results could differ materially from those expressed here; further, the Company is not obligated to comment specifically on those differences. Risks associated with the Company's activities include raising adequate capital to continue operations, scientific and product development uncertainties, competitive products and approaches, continuing collaborative partnership interest and funding, regulatory testing and approvals, and manufacturing scale-up. The reader is encouraged to refer to the Company's Annual Report Form 10-KSB, and recent filings with the Securities and Exchange Commission, copies of which are available from the Company, to further ascertain the risks associated with the above statements.