Protein Polymer Reports Fourth Quarter and 2000 Year End Financial Results

    SAN DIEGO, February 22 -- Protein Polymer Technologies, Inc. (OTC Bulletin Board: PPTI) reports today its 2000 financial results for the fourth quarter and the year, both ended December 31, 2000. For the fourth quarter of 2000, the Company had a net loss applicable to common shareholders of $444,000, or $0.02 per share, versus a net loss of $1,295,000, or $0.10 per share, for the comparable period in 1999. For the year ended December 31, 2000, the Company had a net loss applicable to common shareholders of $2,776,000, or $0.16 per share, versus a net loss of $4,535,000, or $0.36 per share, for the comparable period in 1999. The difference in year end results is due primarily to a significant increase in contract and licensing revenue in 2000, and continued progress in management of expenses. Contract revenues, interest, and product income totaled $525,000 for the fourth quarter of 2000, compared to $13,000 for the same period in 1999. For the year, these revenues totaled $1,189,000, compared to $96,000 for the same period in 1999. The increase in 2000 contract revenue primarily is due to agreements with Femcare, Ltd. providing for rights to register and market the Company's female stress urinary incontinence product in Europe and Australia, the establishment of a technology license with Genencor International to develop and market protein polymers for defined industrial markets, and the license and sale of the Company's in vitro cell culture business to Sanyo Chemical Industries, Ltd. Operating expenses for the fourth quarter were $899,000, as compared to $1,239,000 for the same period in 1999. Operating expenses for the year totaled $3,688,000, compared to $4,353,000 for the same period in 1999. For both the fourth quarter and the year, the decrease in expenditures was due primarily to lower than expected clinical testing costs and a general "across-the-board" Company effort to control costs. However, the cost of clinical testing is projected to rise in 2001 due to expansion of the female stress urinary incontinence product, and the first quarter initiation of clinical testing of the Company's product for dermal contour corrections. As of December 31, 2000, the Company had $866,000 in cash and cash equivalents which the Company believes is sufficient to fund its operations through March 2001. PPTI currently is pursuing a number of alternatives to meet the continuing capital requirements of its operations, including the potential exercise of outstanding common stock warrants, the potential establishment of strategic partnerships and ventures, and potential public or private equity placements. "Our financial results for both the fourth quarter and fiscal year reflect the efforts and expenses associated with bringing our soft tissue augmentation products into human clinical trials," said Dr. J. Thomas Parmeter, PPTI's President and Chief Executive Officer. "Our product pipeline is stronger and better defined than ever before. Our urethral bulking agent is in clinical trials, our dermal augmentation product for use in dermatology, plastic and reconstructive surgery has received IDE approval from the FDA and is scheduled to begin clinical trials within a few weeks, and we've directed the focus of our surgical adhesive technology toward the treatment of lower back pain through Spinal disc repair. We are currently in various stages of discussion with potential strategic partners for both our soft tissue augmentation products and our surgical adhesive product opportunities."

    Protein Polymer Technologies, Inc., a San Diego-based biotechnology company, has developed a protein-based technology platform that allows creation of new biomaterials that can target multiple applications in biomedical markets. The different classes of biocompatible polymers developed by PPTI have been genetically engineered to enable cell growth, promote the regeneration of tissue, bond to synthetic surfaces, and resorb into tissue at controlled rates. Targeted applications include tissue adhesives and sealants, tissue augmentation, wound healing, and drug delivery vehicles.

  This press release may contain forward-looking statements that are based on management's expectations. Actual results could differ materially from those expressed here; further, the Company is not obligated to comment specifically on those differences. Risks associated with the Company's activities include raising adequate capital to continue operations, scientific and product development uncertainties, competitive products and approaches, continuing collaborative partnership interest and funding, regulatory testing and approvals, and manufacturing scale-up. The reader is encouraged to refer to the Company's Annual Report Form 10-KSB, and recent filings with the Securities and Exchange Commission, copies of which are available from the Company, to further ascertain the risks associated with the above statements.
                       Protein Polymer Technologies, Inc.
                          Condensed Financial Statements
                                   (unaudited)


                         Three months ended           Twelve months ended
                            December 31,                  December 31,
                         2000           1999          2000           1999

    SUMMARY OF OPERATIONS

    Contract revenue   $514,156            $--     $1,107,396         $2,320
    Interest income      10,894          9,768         79,087         39,343
    Product and other
     income                  --          3,677          3,012         54,304
      Total revenues    525,050         13,445      1,189,495         95,967

    Total expenses      898,812      1,238,779      3,687,572      4,353,498

    Net loss          $(373,762)   $(1,225,334)   $(2,498,077)   $(4,257,531)

    Undeclared and/or
     paid accumulated
     dividends on
     Preferred Stock     69,980         69,980        277,639        277,639

    Net loss applicable
     to common
     shareholders     $(443,742)   $(1,295,314)   $(2,775,716)   $(4,535,170)

    Loss per share       $(0.02)        $(0.10)        $(0.16)        $(0.36)

    Weighted average
     shares used in
     computing loss
     per share       18,910,313     13,443,510     17,771,744     12,570,987


                                             As of                As of
                                         Dec. 31, 2000        Dec. 31, 1999
    BALANCE SHEET INFORMATION                                     (audited)
    Cash and cash equivalents                $866,000              $156,000
    Working capital                           143,000              (458,000)
    Total assets                            1,383,000               741,000
    Total capital invested                 40,014,000            37,299,000
    Accumulated deficit                  $(39,744,000)         $(37,245,000)