Protein Polymer Technologies Announces Cutbacks In Operating Staff and Operations

    SAN DIEGO, June 25 -- Protein Polymer Technologies, Inc. (Nasdaq: PPTI), today announced that it is reducing its work force by approximately 60 percent. The layoff of eighteen employees is effective as of June 30, 1999. Even under reduced operations, the Company currently has less than two months cash reserves.
    PPTI will continue to focus on preparing for the initiation of human clinical testing of the Company's urethral bulking agent for the treatment of female stress urinary incontinence, and on developing strategic partnering relationships. In May, the Company received FDA approval to begin a pilot study with its incontinence product; actual initiation is dependent upon the Company raising additional cash or completing a partnership agreement. To date, the Company's efforts to consummate a strategic partnering relationship have not met with success, although discussions are still in progress.
    "Conditions in the biotechnology capital markets have made it almost impossible for companies without sales or near-term expectations for FDA product approvals to raise additional capital," said J. Thomas Parmeter, PPTI's President and CEO. "For small public biotech companies, this capital markets problem has been compounded by cutbacks in corporate budgets for research and development, in particular as pertaining to products facing several years of regulatory approvals. We are working hard to surmount these difficulties and hope to be able to restore the Company to full operations in the near future. However, any change in operations is dependent upon completing partnering or equity financing arrangements, and there can be no assurance that this will happen within the time available."
    Protein Polymer Technologies, Inc., is a San Diego-based company focused on developing products to improve medical and surgical outcomes. From its inception in 1988, PPTI has been a pioneer in protein design and synthesis, developing an extensive portfolio of proprietary biomaterials. These genetically engineered biomaterials are high molecular weight proteins, processed into products with physical and biological characteristics tailored to specific clinical performance requirements. Targeted products include urethral bulking agents for the treatment of stress urinary incontinence, dermal augmentation products for cosmetic and reconstructive surgery, surgical adhesives and sealants, scaffolds for wound healing and tissue engineering, and depots for local drug delivery.
  

This press release may contain forward-looking statements that are based on management's expectations. Actual results could differ materially from those expressed here; further, the Company is not obligated to comment specifically on those differences. Risks associated with the Company's activities include raising adequate capital to continue operations, scientific and product development uncertainties, competitive products and approaches, continuing collaborative partnership interest and funding, regulatory testing and approvals, and manufacturing scale-up. The reader is encouraged to refer to the Company's Annual Report Form 10-KSB, and recent filings with the Securities and Exchange Commission, copies of which are available from the Company, to further ascertain the risks associated with the above statements.