Protein Polymer Reports 2nd Quarter 1999 Financial Results and Initial Closing of a New Preferred Stock Offering

    SAN DIEGO, Aug. 17 -- Protein Polymer Technologies, Inc. (Nasdaq: PPTI) reports today its financial results for the second quarter ended June 30, 1999.  In addition, the Company today completed an initial closing of a private placement of its Series G Convertible Preferred Stock with a small group of accredited and institutional investors.  PPTI received approximately $1.8 million at the initial closing.  The proceeds will enable the Company to begin human clinical testing scheduled to begin this fall of the Company's lead product, an injectable treatment for female stress urinary incontinence.
    2nd Quarter 1999 Financial Results:  In the second quarter of 1999, PPTI had a net loss applicable to common shareholders of $1,241,000 ($.10 a share), versus a net loss of $4,786,000 ($.46 a share) for the comparable period a year ago.  For the six months ended June 30, 1999, the Company had a net loss applicable to common shareholders of $2,415,000 ($.21 a share), versus a net loss of $6,133,000 ($.59 a share) for the comparable period a year ago.  The net loss and loss per share include imputed, accumulated and distributed dividends related to the Company's preferred stock.  As of June 30, 1999, PPTI had cash and cash equivalents of $141,000.  On a proforma basis, including the proceeds of the initial closing of the Series G preferred stock, the Company had cash and cash equivalents of approximately $1,900,000 net of offering expenses.
    Contract revenues, interest and product income totaled $20,000 for the second quarter, compared to $45,000 for the same period last year, the decrease being due to reduced contract revenues.  For the six months ended June 30, 1999, these revenues totaled $56,000, compared to $133,000 for the same period last year.  Operating expenses for the quarter were $1,192,000, as compared to $1,496,000 for the same period in 1998.  For the six months ended June 30, 1999, operating expenses totaled $2,333,000, compared to $2,860,000 for the same period last year.  The decrease in both periods is due primarily to reduced research and development expenses and the completion of non- reoccurring preclinical studies required by the U.S. Food & Drug Administration (FDA) prior to beginning human clinical testing.  The Company's product for the relief of female stress urinary incontinence was approved to begin human clinical testing on May 20th.  The Company's expenses are anticipated to rise when the human clinical trials are initiated, currently scheduled for the fourth quarter of 1999.
    For both the 2nd quarter and six month period, the Company continued research and development efforts in its surgical adhesives and sealants program, with particular emphasis on the development of an adhesive Spinal disc repair product for the treatment of lower back pain, in addition to expanding its program in hydrogel-based polymers targeted for use in cosmetic, plastic and reconstructive, and urological soft tissue augmentation surgical procedures.
    Series G Preferred Stock Offering:  Each share of Series G Convertible Preferred Stock is priced at $100 per share, and the total offering of up to 35,000 shares provides for additional closings between now and the middle of September.  Each share can be converted at any time by the holder into common stock at a price of $0.50 per share, subject to certain antidilution adjustments.  Each share of Preferred Stock also receives a common stock warrant, exercisable for 12 months, that allows the holder to acquire 200 shares of PPTI common stock at a price of $0.50 per share.  The Preferred Stock, warrants and underlying common stock have not been registered under the Securities Act of 1933, as amended, and may not be offered or sold in the United States absent registration or an applicable exemption from registration requirements.
    Protein Polymer Technologies, Inc., a San Diego-based biotechnology company, has developed a protein-based technology platform that allows creation of new biomaterials which target multiple applications in biomedical markets.  The different classes of biocompatible polymers developed by PPTI have been genetically engineered to enable cell growth, promote the regeneration of tissue, bond to synthetic surfaces and resorb into tissue at controlled rates.  Targeted applications include tissue adhesives and sealants, tissue augmentation, wound healing, and drug delivery vehicles.
    This press release may contain forward-looking statements that are based on management's expectations.  Actual results could differ materially from those expressed here; further, the Company is not obligated to comment specifically on those differences.  Risks associated with the Company's activities include raising adequate capital to continue operations, scientific and product development uncertainties, competitive products and approaches, continuing collaborative partnership interest and funding, regulatory testing and approvals, and manufacturing scale-up.  The reader is encouraged to refer to the Company's 1998 Annual Report and 10-KSB, and recent filings with the Securities and Exchange Commission, copies of which are available from the Company, to further ascertain the risks associated with the above statements.

                      Protein Polymer Technologies, Inc.

                        Condensed Financial Statements

                                 (unaudited)



                              Three months ended          Six months ended

                                   June 30,                   June 30,

                              1999          1998         1999          1998



    SUMMARY OF OPERATIONS



    Contract revenue           $--           $--          $--       $50,000

    Interest income          6,556        39,909       19,559        48,565

    Product and

     other income           13,868         5,506       36,516        34,295

    Total revenues          20,424        45,415       56,075       132,860



    Total expenses       1,191,746     1,495,632    2,333,496     2,860,314



    Net loss           $(1,171,322)  $(1,450,217) $(2,277,421)  $(2,727,454)



    Undeclared and/or

     paid accumulated

     dividends on

     Preferred Stock        69,220     3,335,936      137,678     3,405,503



    Net loss applicable

     to common

     shareholders      $(1,240,542)  $(4,786,153) $(2,415,099)  $(6,132,957)



    Loss per share          $(0.10)      $(0.46)       $(0.21)       $(0.59)



    Weighted average

     shares used

     in computing loss

     per share          12,505,778    10,471,922   11,727,586    10,450,627





                                         As of                As of

                                     June 30, 1999        Dec. 31, 1998

    BALANCE SHEET INFORMATION                               (audited)



    Cash, cash equivalents and

     short-term investments               $141,000          $1,383,000

    Working capital                       (597,000)            600,000

    Total assets                           846,000           2,225,000

    Total capital invested              35,215,000          34,258,000

    Accumulated deficit                (35,265,000)        (32,988,000)